| Guest Name | Information | Last Appearance |
|---|---|---|
| Benji Rogers | Founder/CEO, PledgeMusic | April 9, 2012 |
| Jay Rogers | President/CEO/Co-Founder, Local Motors | |
| Dan Rooney | Owner, Pittsburgh Steelers | |
| Fabio Rosati | President & CEOElance Inc. | |
| Joe Rose | President, FBS Inc. | June 12, 2012 |
| David Rosen | Sales Representative, Grove Street Wine Brokers | June 4, 2012 |
| Robert Rosenberg | Longtime President & CEO, Dunkin Donuts | June 18, 2012 |
| Joe Rossi | Founder, CEO, Joe's Wildside Adventures | June 12, 2012 |
| Carol Roth | Business Strategist / Author | January 10, 2012 |
| Jim Rudolph | Vice Chairman of the Board, Rita's Italian Ice | June 18, 2012 |
| John Rusbosin | President, Rusbosin Furniture and Flooring | April 24, 2012 |
| Alan Russell | Founding Director, McGowan Institute for Regenerative Medicine | March 23, 2012 |
| Thaddeus Russell | Author | November 22, 2010 |
| Matt Ryan | Assistant Professor of Economics, Palumbo Donahue School of Business | September 2, 2011 |
| Richard Ryan | CEO, Voyager Jet Center | September 23, 2011 |
| Phil Sabo | CPAWilke & Associates, LLP | October 8, 2010 |
| Felix Salmon | Blogging Editor, Reuters | February 6, 2010 |
| Joe Saltmar | Vice PresidentClimatech | March 19, 2012 |
| Harish Saluja | International Filmmaker, Silk Screen Asian Arts | April 17, 2012 |
| Saras Sarasvathy | Professor, Darden School - University of Virginia | |
| Gary Saulson | Executive Vice President and Director Corporate Real Estate, The PNC Financial Services Group | June 14, 2012 |
| Kai Schafft | Associate Professor of Education, Penn State University | June 15, 2012 |
| Mike Schiller | CEO, The Green Buuilding Alliance | June 14, 2012 |
| Phyllis Schlafly | Founder, Eagle Forum / Conservative Pundit | |
| Kenith Schmidt | Principal, Bridge Connections | January 17, 2012 |
| John Schombert | Executive Director, 3 Rivers Wet Weather | March 29, 2012 |
| Christopher Schroeder | Founder, HealthCentral | January 22, 2011 |
| Wil Schroter | Founder & CEO, Go Big Network & GotCast | January 22, 2011 |
| Martin Schwerdtfeger | Senior Economist, TD Bank Financial | June 15, 2012 |
| Tim Scudder | President, Personal Strengths Publishing, Inc. | March 14, 2012 |
| Alan Seadler | Director, Center for Biotechnology, Duquesne University | January 26, 2012 |
| John Sebastian | Senior Vice Presidentdck worldwide, LLC | April 9, 2012 |
| Robert Shapiro | Co-Founder, LegalZoom | March 30, 2011 |
| Gary Shapiro | President, Consumer Electronics Association | February 17, 2012 |
| Stephanie Sheaffer | Marketing, Sherpa Software | March 8, 2012 |
| Emily Shearer | Manager, Training and Interpreting ServicesEcho International | May 22, 2012 |
| Andy Sheldon | President/CEO, Medicago Inc. | January 24, 2012 |
| Hong Sheng | Professor, Missouri U. Science and Technology | March 29, 2012 |
| Kevin Shivers | Pennsylvania State Director, National Federation of Independent Business | March 15, 2012 |
| Amity Shlaes | Author | |
| L. Zane Shuck | Retired professional engineer | April 27, 2012 |
| Sarjoun Skaff | Founder, iLoveRobots | February 18, 2012 |
| Dr. Marvin Slepian | Co-Founder, Chief Scientific and Medical Officer, SynCardia Systems, Inc. | August 25, 2011 |
| Rick Smead | Director, Navigant Energy Consulting | April 6, 2012 |
| Sheryl Winston Smith | Professor, Temple University | May 7, 2012 |
| Diana McLain Smith | Author, Elephant In the Room | May 8, 2012 |
| Kevin Smith | OwnerElite Runners and Walkers | May 12, 2012 |
| Tom Smith | Candidate, United States Senate | January 23, 2012 |
| Edward Snyder | Senior Vice PresidentBill Few Associates | June 14, 2012 |
| Daniel Soeder | Geologist, U.S. Department of Energy (National Energy Technology Laboratory) | April 27, 2012 |